Monday, February 20, 2012

Control your Sugar Levels

https://rcnaegle.relive.com

Products

Blood Sugar Management:

GlucAffect®

GlucAffect is now patented! Learn more.

Now you have a powerful new ally in the wellness war. As part of a healthy lifestyle, patented GlucAffect is clinically shown to help with healthy blood sugar management and support weight loss. The breakthrough formula unites nutrition science’s most cutting-edge ingredients, including Pycnogenol®, Omega 3 fish oils, salacia extract and Glucohelp™ — each of them clinically shown to improve blood sugar management and provides other health benefits. Get in control with GlucAffect.

Proven Effective: In an eight-week clinical study of overweight individuals with elevated blood glucose levels, subjects taking four daily servings of GlucAffect® lowered their fasting blood glucose by an average of 30% and lost an average of nearly 16 pounds.

GlucAffect Works

"For me, GlucAffect is all about quality of life. I've had great results and am living a much healthier, more active lifestyle. If you're open to a solution for blood sugar management, GlucAffect really delivers." ~ Dan Vance, Kaysville, UT

GlucAffect® - Product Reviews"For me, GlucAffect is all about quality of life. I've had great results and am living a much healthier, more active lifestyle. If you're open to a solution for blood sugar management, GlucAffect really delivers." ~ Dan Vance, Kaysville, UT

Greg Johnson of Olympia, Washington, just wants to live a long, normal, healthy life, and the key will be paying close attention to his adult-onset diabetes, a disease he knows can be dangerous if left unchecked.
“Diabetes can creep up on you,” says Greg, a retired school administrator who started taking Reliv’s basic nutrition six years ago in hopes of avoiding some of the complications he’s seen friends and family members suffer as a result of the disease he’s battled himself for 11 years.

Greg’s daily regimen of careful diet, exercise and Reliv shakes was already helping him keep his blood sugar levels fairly stable, but he was excited to give Reliv’s GlucAffect a try as soon as the product was announced.

“I ordered some right away. I was surprised how quickly and dramatically my blood sugar improved once I started taking GlucAffect four times a day,” he says. “Within a week, I noticed the change.” Adds Greg, “I’ve not experienced any complications with this disease yet, and I’d like to keep it that way!”

For eight years, Ria Mastenbrook of Sparta, New Jersey, was nearly completely disabled due to sarcoidosis, an inflammatory disease that affected Ria’s joints, lungs and heart. She was in extreme pain, slept every afternoon for three hours, and could barely take care of her two young children.

Five months ago, she started on Reliv Classic® and Innergize!® and now feels better every day, she says. “Now I don’t have to take long naps,and I’m better able to take care of my kids.”

Ria also suffers from unstable blood sugar, so she decided to try GlucAffect in November.

Since then, she has noticed her blood sugar levels are now consistently in the normal range.

“I felt horrible when I had episodes, but since taking GlucAffect, my blood sugar has remained steady,” she says. “I feel more balanced. I’ve also lost another 5 pounds just by taking two scoops a day. Reliv gives me hope that there could be an eventual end to the physical and emotional strife my family and I have lived.”

Friends and family are starting to notice the healthier Ria, who is a new Reliv Distributor along with her husband, Robert. “GlucAffect is starting to get people’s attention and they’re asking us more about Reliv,” Ria says. “This is our financial future.”

As a Presidential Bronze Ambassador, Joyce Mann of Haysville, Kansas, knows from experience that Reliv nutrition works, so she’s been willing to try new products, including Slimplicity® and GlucAffect.

Joyce discovered Reliv eight years ago when she was helping her husband, Marvin, battle the terminal colon cancer that eventually took his life. She found relief for the joint discomfort, fatigue, allergies, brain fog and short-term memory problems that had plagued her for 25 years.

“I was only 60 years old, but felt like I was 80,” Joyce recalls. “I started on Reliv and my energy went through the roof. I could finally get up and down the stairs again.”
Joyce was also able to shed 15 pounds with Reliv’s Slimplicity and has recently started adding four scoops of GlucAffect to her daily Reliv shakes. She’s been pleased with the
results.

“I was having some night sweats and waking up feeling heavy and tired because of a low thyroid condition,” she says. “But since I’ve added this product, I’m having deeper sleep at night and even more mental clarity. My blood pressure is better, too.”

Reliv Director Sherry Cramer of Charleroi, Pennsylvania, really looks forward to putting a scoop of GlucAffect in her coffee. “It tastes a little bit like hot chocolate with cinnamon,” says Sherry, who started taking Reliv products when was diagnosed with type II diabetes two years ago.

“Staying consistent with Reliv’s basic nutrition really helped me with my high blood pressure, cholesterol and circulation in my feet, so when I heard about GlucAffect, I started taking it right away,” she says. “In just five weeks, I’ve lost nine pounds and my daily sugar readings have improved significantly.”

Sherry says controlling her diabetes and watching her weight can be difficult, especially since she craves carbohydrates and sweets. But she says GlucAffect is helping to curb some of those cravings.

“I’m finding that I don’t think about food all of the time,” she says. “I used to start thinking about what I was going to have for dinner while I was eating lunch. Now I can focus on other things and not feel like I need to nibble on something. That craving for something sweet just isn’t as strong. And I feel great!”

Two years ago at the age of just 31, Sara Shields of Siletz, Oregon, already had many symptoms of metabolic syndrome. She was overweight, apple-shaped, and had high cholesterol and high blood sugar. Her doctors told her she would likely have diabetes by age 35 if she didn’t make some lifestyle changes.

But Sara was in a Catch-22. She tried to lose weight but couldn’t exercise much because of back problems. In May 2008, she began taking Reliv’s basic nutrition, which helped alleviate some of her back discomfort. Her energy was improved, but her weight still dragged her down.

Things began to turn around the following November when Sara added GlucAffect to her daily shakes. In two months, she lost 16 pounds and noticed her blood sugar leveled out, even after meals.

“GlucAffect gave me the extra boost to start losing weight,” Sara says. “With the weight loss it was easier to work out, so now I’ve joined a gym and am walking regularly. Before when my blood sugar was high, I felt very lethargic, bloated and grumpy. Now that my blood sugar has stabilized, I feel so much better and don’t even crave sweets anymore.”

As a Reliv Master Affiliate, Sara says GlucAffect is also giving her a new avenue to talk to more people. “It’s given me an edge and opened doors. I’m much more active in my business now.”

Manley Lane, a 10-Star Key Director from Bath, Maine, has seen significant improvements with his health since starting on Reliv products two years ago.

“When I was introduced to Reliv, I was suffering from two auto-immune diseases, causing needle-like shocks that radiated throughout my legs,” Manley recalls. “I wound up losing my ability to drive and pretty much was confined to a wheelchair.”

Within three months of starting on Reliv’s basic nutrition, Manley was preaching at his church standing on his feet, rather than sitting in a chair. “The other day, I hiked to a fishing pond with a four-pound pack on my back!” he notes. “I never before realized the importance of great nutrition for our bodies.”

Now Manley has added GlucAffect to his nutrition regimen, and is reporting even more results. “At my annual physical, I weighed five pounds less than the previous year,” he states. “My blood pressure has improved, and my blood sugar has stabilized.

“I now have even more energy and vitality than before — and new people are joining my organization as the direct result of this new product,” Manley adds. “GlucAffect has added a whole new dimension to both my health and my business!”

Presidential Bronze Ambassador Valerie Opie of Mesa, Arizona, is seeing some surprising new results — particularly in her mid-section — since starting on Reliv’s newest product, GlucAffect. “In the six weeks I’ve been on the product, I’ve lost an inch around my waist and three inches of belly fat,” Valerie reports.

Perhaps even more exciting to Valerie has been watching her 13-year-old son, Samuel, achieve his own results with GlucAffect.

“In just one week, Samuel lost 10 pounds and dropped a pants size,” Valerie states — adding that, after also losing between 10 and 15 pounds earlier with Simplicity®, Samuel is now at his ideal weight.

The introduction of GlucAffect has helped Valerie reignite her Reliv business, as well. “I stepped back from my business after our house burned down two-and-a-half years ago,” she explains. “GlucAffect has given me a reason to re-visit everyone about Reliv, and now my business is booming again!

“Right now, there is a huge market of people looking for exactly what Reliv has to offer — effective and affordable targeted solutions to specific health issues,” Valerie adds. “I’ve never been more excited about Reliv than I am right now!”

Bill Albert is a retired trucker from Boonton, New Jersey, who had already gotten great results with a number of Reliv products. Then last fall, when he added GlucAffect, things got even better.

“I was quite a bit overweight and that certainly aggravated the osteoarthritis in my hips,” Bill says. “I combine GlucAffect with several other products, add a little fruit and make up a smoothie. By leveling out my blood sugar levels, my cravings to snack all day long have disappeared — I’ve lost 25 pounds and I have more energy than I’ve had in years. My primary care physician at the local VA Clinic told me, ‘I don’t know what you’re doing, but keep it up!’

“I tell people you don’t have to believe me — just try it for yourself,” Bill continues. “Some people have told me ‘nothing could work that well,’ but if they try it themselves, they get amazing results. Adding GlucAffect to the other Reliv products has made a huge difference for me — at 65, I feel 10 years younger. I swear by it!”

Ellen Alo, from Simpsonville, South Carolina, discovered she had high blood sugar during routine tests in 2000. “I had serious fibromyalgia issues. And I was getting results with a number of Reliv products,” she says. “But my blood sugar was still high and my doctor put me on insulin.”

When GlucAffect was launched last November, Ellen was eager to see how it might help her. “I feel so much better now,” Ellen says. “My blood sugar now tests on the low end of the scale, I have much more energy and both my triglycerides and cholesterol levels have come down… and I’ve dropped five pounds!”

Ellen appreciates the versatility of GlucAffect — she mixes it into her regular shake, or takes it in a cup of hot tea. But what she likes best about the new product is the way it helps manage her blood sugar. “When my blood sugar was too high or low, it affected my energy levels,” she says. “Since I’ve started using GlucAffect, I am on much more of an even keel.

“I’ve talked with many people who complain about tiredness and big swings in energy,” she continues. “And I tell them I have something that could do for them what it has done for me, and that’s GlucAffect!”

After 18 frustrating years of high, wildly fluctuating blood glucose numbers, type 2 diabetic Ray Doerr of Rochester Hills, Michigan, has discovered new hope in GlucAffect.

“For years there seemed to be no cause and effect between my blood glucose readings and what I ate, how much I slept or how I exercised,” says Ray, who recently retired after more than 39 years as an engineering and manufacturing manager for a U.S. automotive company.

Earlier this year, Ray started taking four daily servings of GlucAffect and Simplicity® mixed with water. In two months, he dropped 18 pounds and stabilized his blood sugar numbers at a healthy level for the first time.

“Thanks to these two products I feel like a new man,” Ray says. “I’m standing taller, walking straighter and I have more energy. Most importantly, I have developed a much more hopeful outlook on life.”

Camille, Ray’s wife of 40 years, has experienced good results from taking Arthaffect® to alleviate pain in her knee from a surgery a year-and-a-half ago.

“I can only speak of the results we’ve achieved,” Ray says, “but we’re both extremely enthusiastic and positive about these products.”

Don Braun, of Milwaukee, Wisconsin, struggled with high blood sugar for years. A Type II diabetic, Don worked hard to keep his levels in an acceptable range. Any variation in his diet — a sandwich along with a salad at lunch — would send his levels way up.

In 2007, a friend introduced Don to Reliv. He began a regimen of several shakes a day, combining five different products and bringing his sugar levels down from a high of 399 to between 130-150 — and made his doctor happy. But when GlucAffect was unveiled, Don embraced the new product, ordering a couple of cases. Now his levels are steady in a healthy range of 110-125!

Don experienced two very interesting effects of GlucAffect. “One shake before bed, I sleep like a brick. But if I have a shake before I walk or exercise, I get a couple of hours of extra energy. I take four GlucAffect shakes a day, and I’ve cut down on my use of other products, so GlucAffect has really paid for itself.”

And, Don adds, “While I still watch my diet, that occasional sandwich does not send my blood sugar back up. And spiced apple tea, hot or cold, mixed with GlucAffect is delicious!”

Lore Raatz, a high school teacher in Gillett, Wisconsin, uses GlucAffect to help manage her hypoglycemia. She began taking Reliv products in 2007 to aid in her recovery from an unsuccessful heart surgery.

She says the products helped her regain her energy and to avoid a second heart surgery. “When GlucAffect came out, I starting taking it because a very high percentage of hypoglycemics develop type 2 diabetes later in life,” she says. Lore mixes one scoop a day of GlucAffect with her regular shakes, and admits to loving the taste.

“Within the first three weeks of using GlucAffect, my blood pressure had gone down and the swelling in my ankles had gotten much better,” she says. “I just had my complete blood work done and my blood pressure and fasting blood sugar levels were wonderful. I can’t remember the last time that happened.”

Lore’s husband, Rick, uses GlucAffect for prevention because diabetes runs in his family. They are sharing it with friends and family who have a higher risk of diabetes in their lives.
Lore’s heart condition is regenerative. “I will never stop taking Reliv’s products,” she says. “Everybody can benefit from them, but I need them from the bottom of my newly healed heart!”

For more than 20 years, Judy Niemuth, 64, of Hawthorn Woods, Illinois, watched her mother battle diabetes and struggle with her health. Last October, at age 85, Judy's mother passed away from a massive heart attack.

"I was emotionally and physically devastated," Judy says. "I am also an overweight diabetic, so in addition to mourning for her, I was frustrated and worried about my own condition. But I realized I still had time to change my life."

Judy started taking GlucAffect, and after five months says she has lost 30 pounds and watched her glucose levels plummet from an average daily level of 268 down to 115.

"I am ecstatic about these changes and I can only get better," she says. "I am now taking Reliv essential nutrition with GlucAffect two or three times a day. I am convinced that if I stay on Reliv's products and continue to lose weight, I will no longer be in harm's way because of my diabetic condition. My goal is to maintain my diabetes the healthy way — the Reliv nutritional way. And I can't wait to help others and tell the whole world about my success story. It truly has been a miracle for me!"

Ambassador Paula Coffey of Millersburg, Ohio, and her husband, George, hold regular GlucAffect calls with their Distributors. Most have customers using it with remarkable results. One couple even joined Reliv as Master Affiliates because of it! “He is a diabetic so they wanted the product,” explains Paula. “When I told them about the opportunity to build a business around GlucAffect, they came into the business at the top profit level. They wanted to be the first to market it and were thinking of family members and friends they could help.”

We all know people who have diabetes or who need help managing their blood sugar levels, notes Paula. “GlucAffect has clinical trial results supporting that it just flat-out works,” she says. “When people get amazing results, they share their stories and then those people want GlucAffect, too. This is an awesome nutritional product and an amazing business opportunity.”

The Coffeys “walk the talk.” George’s 83-year-old mother uses GlucAffect and Paula takes it in her daily shakes, despite having no blood sugar problems. “I like the way it tastes and I crave those healthy ingredients,” she says. “Dr. Carl has come up with a wonderful product — there is nothing out there that compares.”

When Mark Selman of Alpharetta, Georgia, learned that his fasting blood sugar level had reached 124, and his doctor started talking about medication, it “shocked” him enough to give GlucAffect a try.

“I told my doctor about GlucAffect, and that I planned to take the product consistently four times a day, just like in the clinical trial,” Mark reports.

At his follow-up appointment two months later, Mark learned that his blood sugar level had lowered to 97, which is within the normal range. And his weight was down, as well. “I’d lost 15 pounds, and I’ve since lost five more,” Mark states.

“I give a lot — if not all — the credit to GlucAffect,” he continues. “I’ve never been able to lose this much weight before through diet and exercise alone — and I love the taste!

“My parents both died of cancer, and I’ve been taking the Reliv basic nutrition for the past four years primarily as a preventative measure,” Mark adds. “I know that, by eating right, exercising regularly, and now adding GlucAffect to my nutritional regime, I’m doing everything I can to maintain optimum health, now and in the future.”

About a year ago, Brian Edelstein was diagnosed with type 2 diabetes. Brian, who lives in a Chicago suburb and works as a project manager in the printing industry, immediately changed the way he ate and stepped up his exercise program. He did everything his doctors advised.

When Reliv introduced GlucAffect last November, Brian’s brother, Alan, suggested that he try this new product to help further reduce his blood glucose levels.

“I thought I should try it if it was something that could help more,” remembers Brian. “So I started taking one scoop of GlucAffect every day with my morning coffee. Within a couple of weeks, my blood sugar levels began to dip.”

Motivated by those initial results, Brian began mixing Glucaffect with other basic Reliv products in regular morning and evening shakes. A recent blood test revealed that his A1C level had dropped from 6.5 to 6.0 since he began taking GlucAffect. Brian says he is sleeping better and has much more energy.

“It’s exciting to feel better and to talk to other people experiencing the same positive results,” adds Brian, who has since become a Master Affiliate. “I can’t say enough great things about this product!”

Senior Director Bill Guilford of Alpharetta, Georgia, has always done the right things to stay in shape. He eats a healthy diet and exercises regularly, doing both cardio and weight training. Yet, seemingly out of nowhere last year, Bill started to gain weight.

“I wound up gaining fifteen pounds, mostly around my mid-section,” Bill recalls. “I figured it was just a part of turning 50.”

“When GlucAffect came out, I immediately called my mom to find out who she knew that had diabetes and could benefit from the product,” he continues. “And I was shocked to find out that diabetes runs rampant in my family — my aunt, uncle and both sets of grandparents all have the disease.”

Concerned that perhaps he was experiencing the onset of diabetes, Bill began taking GlucAffect four times a day, while maintaining his diet and exercise regime. “I’ve since lost 18 pounds and am literally in better physical shape than I was in my twenties,” Bill states. “And my blood sugar level is in the mid 80s, which is fantastic.

“Now I know that I don’t have to look a certain way just because I’m older,” he adds. “This product is phenomenal!”

For Angela Hosman of Surprise, Arizona, GlucAffect could not have arrived at a more critical time.

“My blood sugar levels were dangerously high, between 300 and 400, and the neuropathy in my feet had spread all the way to my knees,” Angela says. “My doctor informed me that, if I didn’t get my blood sugar under control, I would lose my legs by the time I was 35 — and that my only option was an insulin pump, a highly invasive procedure which I was desperate to avoid.”

Introduced to GlucAffect by her mother-in-law, Angela began taking the product “religiously” four times a day. “After six weeks on the product, my blood sugar had dropped to a normal range of between 80 and 100!” Angela states.

And that wasn’t the only thing that dropped during those six weeks. “I also lost 13 pounds,” she reports. “And, since I’ve started taking the Reliv basic nutrition, I’ve lost a total of 29 pounds — That’s 19 percent of my body weight! I feel absolutely awesome, and I’ve been told that the sparkle is back in my eyes.”

Angela and her husband now hope to have a baby some day. “I never thought I would be able to drastically change my life like this,” she says. “To me, GlucAffect is a miracle — I’ll never go without it!”

After just one month as a Reliv Distributor, Director Jen Zehner of Salem, Oregon, has discovered firsthand that the way to jump-start a new business is by sharing the opportunity with everyone. She’s leading with the business, using Reliv’s newest product, GlucAffect, as an entry point. Aware that her grandmother, Marilyn, had recently been diagnosed with diabetes, Jen invited Marilyn — along with her father and sister — to a Reliv Special Event.

“They all started on the products, and my grandmother became a Master Affiliate that same day,” Jen states.

At the top of Marilyn's list of people to contact about Reliv was her neighbor, Nora, who suffered from neuropathy in her legs and feet, and had already lost a toe as a result of diabetes.

“I set an appointment with Nora, including my upline, so that she could hear the whole Reliv story,” Jen recalls. “And while Nora wasn’t sure about the business at first, she did start on the product right away — and she referred me to her friend, Judy, whom she knew was looking for a business opportunity.

“GlucAffect is so powerful,” Jen adds. “Its results can be proven so quickly that you can literally build a business around it. And with more people than ever in need of this product, I’m really excited about my future with Reliv!”

Steve Tucker is a former autoworker from Affton, Missouri. In the years before he retired, Steve underwent a series of surgeries to repair his foot after it was crushed in a workplace accident.

These surgeries sent Steve into a prolonged period of inactivity that led him to gain 80 pounds. A visit to his doctor for a physical confirmed his fears: “Everything my doctor told me was bad,” he says. “In addition to being overweight, my blood pressure was high, all my cholesterol levels were bad, my triglycerides were off the chart and my blood glucose level was averaging over 260.”

In response to this bleak report, Steve began drinking four Reliv shakes a day containing GlucAffect. He added CardioSentials® to two of these shakes. The rapid results surprised everyone — including his doctor.

“Within a couple of weeks, my daily blood sugar numbers were down around 150,” says Steve. “When I went back for my six-week checkup, my numbers across the board were near the healthy range.”

Steve also has changed his eating habits and established a daily exercise routine. “I’ve lost 21 pounds and in just six short weeks I have gotten my life back into my own hands” he says. “It’s wonderful!”

Brenda Fettig, a Reliv Director from East Helena, Montana, didn’t realize just how unhealthy she was until she started feeling better with Reliv.

“I think sometimes you just don’t realize what you’re missing out on,” says Brenda, who was diagnosed as a Type II diabetic in October 2007. “Diabetes runs in my family on both sides, and I knew I was at risk, but I guess I was so busy putting everyone else first, that I didn’t take it seriously.”

Brenda and her husband have four children and served as foster parents for 13 years. She says she was tired and sick much of the time, and also overweight. She’d already lost 100 pounds when she started taking Reliv. The products gave her relief from chronic sinus and ear infections.

GlucAffect did even more for Brenda, relieving tingling and numbness in her feet and reducing the spikes and drops in her blood sugar levels.

“Now, when somebody has a birthday, I can eat a little cake and ice cream without a problem,” she says. “I’m so thankful because I feel so much better. I’ve got to take care of myself because I need to be around for all of my children.”

Long before GlucAffect came about, Master Director Vicki Leslie of Fort Worth, Texas, had already achieved amazing results with Reliv.

“My husband is always saying that I wouldn’t be alive today if it weren’t for Reliv,” Vicki notes. “Before Reliv, I was spending my days in bed, overwhelmed by the symptoms of chronic fatigue syndrome, fibromyalgia and migraine headaches.”

Still, when it came to her weight, Vicki continued to struggle. “I have many of the traits that are characteristic of metabolic syndrome — my waistline is over 34 inches, and my cholesterol and triglyceride levels are on the higher side,” Vicki states. “So I was really excited when Reliv introduced GlucAffect to the market in mid-November.

“I started on the product immediately and, after just one week, I lost five pounds!” she continues. “I since have lost a total of 17 pounds, and my cholesterol and triglyceride levels are lowering for the first time in years.

“Reliv has made a huge difference in my quality of life over the past seven years,” Vicki adds. “And now that we have Glucaffect, I’m looking forward to the day when my weight is within the normal range, and I look as good on the outside as I feel on the inside!”

When Senior Directors Capt. Steven and Dee Ann Lucks of Idaho Falls, Idaho, first heard about Reliv GlucAffect, they literally cried for joy.

“Our daughter was diagnosed with diabetes at age nine, and has suffered from this chronic, debilitating disease for 12 years now,” Dee Ann states. “So we were honestly overwhelmed that Reliv had developed a product that could help her.

“Our daughter has what her doctor likes to call ‘Type III’ diabetes, because she has the symptoms of both Type I and Type II diabetes,” Dee Ann continues. “Type I, because her pancreas no longer produces insulin, and Type II, because she is insulin-resistant.”

On the morning that the Lucks’ daughter started on GlucAffect, her fasting blood sugar level was 292, well above the normal range of 70-to-100.

“Within eight days of taking four scoops of GlucAffect per day, her blood sugar had dropped to 151,” Dee Ann states. “Over the next six weeks, it dropped to as low as 63, with an average of 136!

“The clinic where her doctor works has been involved in diabetes research for the past ten years, and everyone there is very impressed with her results,” Dee Ann adds. “There is no other product out there that can do what GlucAffect does — it truly is ground-breaking.”

The statements contained in this material have not been evaluated by the Food and Drug Administration. The personal testimonials shared reflect individual experiences of Independent Reliv Distributors and are not necessarily typical of the results you may obtain. Reliv products are not intended to diagnose, treat, cure or prevent any disease.

Reliv GlucAffect®
Blood Sugar Management

Download printable pdf

It has.... (Features)	Which means... (Benefits)
A combination of cutting-edge ingredients brought together for the first time…	…nothing else like it exists. All ingredients have been selected using amounts proven effective in clinical studies and have been formulated to work together for maximum results in maintaining healthy blood sugar levels.
An eight-week, placebo-controlled clinical study supporting overall product effectiveness…	…it’s proven! As part of a regimen of healthy diet and exercise, test subjects taking four servings daily of GlucAffect significantly lowered blood fasting glucose and experienced substantial weight loss.
Pycnogenol®…	…you receive the benefits of a natural super-antioxidant, proven to help lower blood glucose levels, LDL (“bad”) cholesterol and blood pressure and improve overall health.
Omega 3 Fish Oils…	…it promotes cardiovascular health and helps maintain optimum blood pressure and cholesterol levels.
Madeglucyl™, Glucohelp™, Silbinol®, salacia extract, alpha lipoic acid and more…	…it contains many advanced ingredients clinically proven to support blood sugar management and neutralize free radicals.
Cinnamon cream flavor…	…you’ll enjoy a delicious natural cinnamon taste. Research also shows that cinnamon may help combat insulin resistance and improve hemoglobin levels in people with type 2 diabetes.
Rapid dissolvability…	…it’s a perfect addition to your morning coffee, afternoon tea or one of your daily Relìv shakes.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

GlucAffect®
Frequently Asked Questions

1. Who should take GlucAffect?
Anyone seeking nutritional support, as part of a healthy lifestyle, for help with maintaining healthy blood sugar levels and aiding in weight management.

2. Does GlucAffect cure metabolic syndrome and prevent diabetes?
No. Like all Reliv products, GlucAffect is not intended to diagnose, treat, cure or prevent any disease. It is instead a nutritional supplement designed to support blood sugar management and aid in weight loss as part of a healthy lifestyle of proper diet and exercise.

3. Has GlucAffect been recommended by doctors to address diabetes?
No.

4. Can I take GlucAffect if I am a diabetic or hypoglycemic?
If you are diabetic or hypoglycemic consult your doctor before taking GlucAffect. GlucAffect should be consumed by those receiving treatment for blood sugar-related conditions only as part of a physician-approved program.

5. Can I take GlucAffect if I am pregnant?
If you are currently pregnant, breast-feeding, or planning on becoming pregnant, please discuss this product with your physician before using GlucAffect.

6. Can GlucAffect be used as a substitute for prescribed medications or insulin treatments?
No. Do not use GlucAffect in place of any physician-directed course of treatment. If you are receiving treatment, be sure to consult your physician before taking GlucAffect.

7. What are the active ingredients in GlucAffect?
For a summary of key ingredients, download the online product guide.

8. Is there any research to support GlucAffect's effectiveness?
Yes. In an eight-week, placebo-controlled clinical study of overweight individuals with moderately elevated blood sugar levels, test subjects taking four daily servings of GlucAffect as a meal replacement and participating in a diet and exercise program lowered their fasting blood glucose by an average of 30% and lost an average of nearly 16 poweeksunds, while their BMI (body mass index) improved from an average of 26.8 down to 24.5, back into the healthy range. No significant glucose lowering or weight loss was found in the control group. In addition, the active ingredients in GlucAffect have been clinically shown to help support blood sugar management and promote overall health.

9. Have the clinical trial results been published?
Yes. Read more about the clinical trial.

10. Should I take GlucAffect as a meal replacement like those in the clinical study?
No. GlucAffect is a dietary supplement and not a meal replacement product. We recommend 1-4 servings a day as part of a healthy diet. If you are looking for a meal replacement product, we recommend Reliv's Slimplicity Weight Loss System.

11. Does GlucAffect have any side effects?
In clinical trial, all participants completed the study and reported no significant negative side effects after taking the product for eight weeks.

12. How long before I can expect to see results?
Individual results will vary. We recommend trying the product for four weeks.

13. What can I mix GlucAffect in?
GlucAffect's delicious cinnamon cream flavor and rapid dissolvability makes it the perfect addition to your morning coffee, afternoon tea or one of your daily Reliv shakes.

14. Can I take GlucAffect with other Reliv products?
Yes. GlucAffect may be taken alone or with any combination of Reliv products.

15. I currently use Slimplicity® for weight management. Can I use GlucAffect instead?
While those in the study did experience significant weight loss results, GlucAffect remains a product designed primarily for supporting healthy blood sugar management. For best results with both weight loss and blood sugar management, we recommend taking the two products in combination.

Glucaffect® Clinical Trial Confirms GlucAffect Works

Download printable pdf
Daily consumption of GlucAffect dietary supplement has been clinically shown to help lower blood glucose levels and aid in weight loss. In an eight-week clinical study, 50 overweight subjects with moderately elevated fasting blood glucose, criteria for metabolic syndrome, were randomly assigned to either receive four daily servings of GlucAffect nutritional supplement or an inactive control product with identical taste, color and texture as a meal replacement. They also agreed to participate in a diet and exercise program. Test subjects taking GlucAffect lowered their blood fasting glucose by an average of 30%, moving from elevated glucose levels to healthy blood sugar values. The lowered blood glucose was confirmed by the average HbA1c (glycosylated hemoglobin) level, which also moved into the healthy range. No significant glucose lowering was found in the control group. In addition, those individuals taking GlucAffect lost an average of nearly 16 pounds during the eight-week period, slimming to an extent on average that they achieved their optimal BMI (body mass index). No significant effect on body weight was found in the control group.

In creating GlucAffect, we included ingredients clinically shown to help address blood sugar management using amounts that had already been proven effective, so we expected good results. But even we could not have expected such a dramatic outcome in just eight weeks. Needless to say, we're thrilled with the results and eager to share this product with the world. Dr. Carl W. Hastings
Reliv Vice Chairman and Chief Scientific Officer

GlucAffect Nutritional Panel

Discover the unique blend of ingredients that makes this product unlike any other nutritional supplement available today.

GlucAffect

https://rcnaegle.reliv.com

Sunday, February 19, 2012

Discussion on the Immune Response Called Imflammation

Print Email Facebook Twitter Digg

Article

Friday Pearls

Inflammation 101

February 17, 2012

Throughout most of human history, the main threats to human life and health have been the germ diseases: smallpox, bubonic plague, tuberculosis, dysentery, influenza, typhoid fever, etc. In the developed world these diseases have been mostly eradicated over the past century, and a new set of diseases have become the main causes of debility, illness and death.

The illnesses/conditions that plague the industrialized nations include allergies, asthma, age-related frailty, Alzheimer's disease and other dementias, arthritis, atherosclerosis, cancer, congestive heart failure, chronic fatigue/fibromyalgia, depression, diabetes, heart attack, inflammatory bowel disease, kidney disease, lupus, macular degeneration, osteoporosis, periodontal disease, overweight/obesity, skin disorders, stroke and surgical complications.

Surprisingly, modern science has discovered a common denominator to all these conditions, and it isn't germs. It is inflammation. (1-8), (14-24), (43) And while germs may be considered enemy aliens who invade our bodies, inflammatory conditions are created by our own physiologic reactions. As Pogo wisely stated, "We have met the enemy and it is us."

Inflammation 101

Mosby's Medical Dictionary defines inflammation as "the protective response of body tissues to irritation or injury. Inflammation may be acute or chronic; its cardinal signs are redness, heat, swelling, and pain; often accompanied by loss of function.(9)

While acute (sudden onset) inflammation is often obvious (such as the redness, swelling, pain and tenderness from a cut), chronic inflammation, such as occurs in the linings of heart arteries in atherosclerosis, may have no visible or obvious signs or symptoms. Such "invisible" chronic inflammation may properly be called "silent inflammation."

Inflammation is an immune response, "designed" to protect us from germs, wounds or injuries. Without adequate inflammatory responses, life would not last long. Any germs invading our bodies would quickly overwhelm us. Wounds and injuries would not heal. New healthy tissues would not replace damaged tissue.

In a world without sanitation and full of germs, such as faced mankind prior to the 20th century (and still does today in the "underdeveloped" world), a vigorous inflammatory response is the key to health and longevity. A genetically weak inflammatory response would typically mean death in infancy from some germ disease.

Ironically, a genetically vigorous inflammatory response that is highly protective in a world of poor sanitation, full of germs, may serve to limit longevity in a world such as ours, where germs have mostly been conquered. This is because such vigorous inflammatory response tends to promote cancer with aging. (10)

The inflammation response involves a large cast of characters. White blood cells such as neutrophils, monocytes/ macrophages, basophils, eosinophils will speed to the inflamed area. (11) Cytokines, hormone-like immune proteins, will be secreted by various cells. Interleukin-1 and -6 and tumor necrosis factor-alpha are some of the most important inflammatory cytokines. (3) Tissue-swelling chemicals such as bradykinin, histamine and serotonin may be released. (11) Inflammatory prostaglandins and leukotrienes will further amplify the inflammatory response. (11)

In response to circulating interleukin-6, the liver will release acute phase reaction products, such as C-reactive protein and fibrinogen. (12), (13). In response to these pro-inflammatory biochemicals, white blood cells will secrete oxidants and free radicals to kill germs, and enzymes to dissolve dead and dying cells.

Unfortunately these oxidants and enzymes may harm healthy cells. The white cells may also burrow into tissues, such as artery linings, where they may cause unintended damage to the body's own tissues.

Eventually, other factors will turn off the inflammatory response as germs are disposed of and tissues begin to heal. If the inflammation response takes on a life of its own, becoming self-perpetuating, chronic inflammation develops. Chronic, "silent" inflammation is believed to be intimately involved in the development of obesity, insulin resistance, diabetes, cancer, heart disease, and Alzheimer's and other dementias. (14) (23).

Chronic Inflammation and The Modern World

In a healthy person the inflammation response is tightly controlled. It is only activated when there is a need from a germ invasion, a wound, tissue injury (such as a sunburn), a broken bone, etc.

Unfortunately, scientists have discovered that a host of factors all too common in the modern, developed world tend to promote out-of-control, chronic inflammation. Overweight/obesity (by some estimates over half of all Americans are overweight or obese), insulin resistance, sleep deprivation, hypokinesia (too little physical work/movement), mega-stress, aging, and improper diet are just some of the all-too-common promoters of chronic inflammation.(3), (10),(15), (16), (24), (25), (33) (35)

The Inflammatory American Diet

The typical American diet almost looks as if it were designed to promote chronic inflammation. The processed-food American diet, once rich in trans-fatty acids, produced when vegetable oils are hydrogenated. Margarines, salad dressings, chips and baked goods such as cookies and crackers are just some of the dietary sources of trans-fatty acids. Research has shown these abnormal fatty acids to be inflammation promoters. (28) (30). Any oils still labeled "partially hydrogenated" tend to be rich sources of trans-fatty acids.

A diet rich in rapidly digested sugars/starches (high glycemic), especially when consumed by those overweight and/or insulin resistant (and such a diet promotes overweight/insulin resistance), promotes inflammation.(31). The typical American diet is rich in carbohydrates, with roughly two-thirds of the average American's carbohydrates coming from inflammation-promoting high-glycemic foods, such as bread, soft drinks/sodas, cakes, cookies, quick breads, doughnuts, sugars/syrups/jams, potatoes, cereal and pasta. (32)

Advanced glycation end products (AGEs) also promote inflammation.(36), (37). While AGEs are formed in our bodies, especially when blood sugar is frequently elevated, (38) they can also be absorbed from the diet. (36) ,(37). A diet high in pre-formed AGEs can seriously elevate blood levels of various inflammatory mediators, including C-reactive protein, tumor necrosis factor-alpha, and vascular cell adhesion molecule.(36), (37). A low-AGE diet can lower these inflammatory bio-chemicals.(36), (37).

What promotes the formation of AGEs in food? High heat/prolonged cooking.(36), (37) Deep-fried foods, such as French fries, fried fish and shrimp, fried chicken, etc. are great sources of AGEs. Well-done meats (including typical fast-food burgers), overly-crisp bacon, indeed anything cooked with high heat or for prolonged periods provides an AGE-rich diet.

The Vegetable Oil Connection

A major contributor to chronic inflammation in modern America is the over-consumptionof the vegetable oils associated with overly-processsed junk food, especially corn, safflower, soy, peanut, cottonseed, sunflower and canola oils. These oils are rich in the omega-6 fatty acid linoleic acid. (39), (40). In the body, unbalanced linoleic acid can be metabolized to arachidonic acid. (39) (40).

Arachidonic acid is the raw material from which the body makes a broad range of pro-inflammatory biochemicals. (39),(40). When arachidonic acid is processed by cyclooxygenase enzymes, inflammatory prostaglandins and thromboxanes can be produced. (39), (40). When arachidonic acid is processed by lipoxygenase enzymes, inflammatory leukotrienes can be produced. (40).

Vegetable oils are a recent addition to the human diet. They only came into widespread industrial production in the 1920s. Over the past 50 years, as the anti-cholesterol medical/dietary establishment has told Americans to reduce their saturated fat intake, it has hyped the intake of linoleic acid-rich vegetable oils.

The common use of vegetable oils has caused a historically unprecedented shift in the diet-induced inflammatory balance. Linoleic acid can metabolize to a powerful inducer of a pro-inflammatory micro-environment in the cells that line our arteries and veins. (41).

Not only does high linoleic acid intake promote elevated levels of inflammatory prostaglandins, thromboxanes and leukotrienes,(39), (40), but it can also activate other powerful inflammatory molecules, including tumor necrosis factor-alpha (which in turn activates the super-inflammatory interleukin-6 and nuclear factor kappa Beta, (41). Nuclear factor kappa Beta in turn has the power to turn on the genes that promote production of over seven other pro-inflammatory cytokines and biochemicals. (55).

Omega-3s and the Modern American Diet

The good news is that the dietary counterbalance to linoleic acid/arachidonic acid is provided by the omega-3 fatty acids, alpha-linolenic acid and the fish oil fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). (39), (40). EPA at adequate blood/cellular levels can reduce conversion of linoleic acid to arachidonic acid, and reduce the conversion of arachidonic acid to inflammatory prostaglandins, thromboxanes and leukotrienes. (40).

In the vegetable oil-rich typical American junk food diet of the past 50 years, the omega-6-to-omega-3 dietary ratio tends to be inbalanced. This is due both to a reduction of dietary levels of omega-3 fatty acids, as well as an increase of omega-6 fatty acids. (39), (40). Thus the severely imbalanced fatty acid profile of the typical modern American diet has profoundly shifted our cellular biology to a pro-inflammatory status. The most biologically efficient way to balance fatty acid intake is to clean up your diet. Popping excessive amounts of fish oil capsules to balance a high junk food diet does not promote good health.

Obesity and Inflammation

A majority of the American population is now considered overweight or obese. Recent research has established that obesity is a major contributor to the chronic inflammatory state. According to researchers Lee and Pratley, "Obesity is characterized by a chronic, systemic low-grade state of inflammation. Biomarkers of inflammation, such as the leukocyte [white blood cell] count, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and C-reactive protein, are increased in obesity, associated with insulin resistance, and predict the development of type 2 diabetes and cardiovascular disease. It is now clear that the adipocyte [fat cell] is an active participant in the generation of the inflammatory state in obesity. Adipocytes secrete a variety of cytokines, including IL-6 and TNF-alpha, that promote inflammation. Moreover, recent studies suggest that obesity is associated with an increase in adipose [fat] tissue macrophages [white blood cells], which also participate in the inflammatory process through the elaboration of cytokines.(24).

A recent human study has shown that the blood levels of two key inflammation molecules, interleukin-6 and C-reactive protein, increase as obesity intensifies. (26). There is growing evidence that the inflammatory cytokines secreted by fat cells, such as interleukin-6 and tumor necrosis factor-alpha, promote increased obesity, as well as insulin resistance. (16), (25), (42). Interleukin-6 stimulates the liver to release C-reactive protein, (13) and there is evidence that high C-reactive protein levels promote the development of type 2 diabetes. (17)

Sleep Is Not A Luxury

A.N. Vgontzas and colleagues have done human research that makes it clear that sleep deprivation promotes a pro-inflammatory environment. (33) (35). "Sleep deprivation leads to sleepiness and daytime hypersecretion of IL-6.(34). In an experiment with 25 healthy, normal sleepers, Vgontzas and associates measured the effects of decreasing sleep from eight hours nightly to six hours nightly for one week. (35). They found that in both men and women, there was a 40-to-60-percent increase in interleukin-6 secretion, while in men there was also a 20-to-30-percent increase in tumor necrosis factor-alpha. They concluded "in young men and women [presumably healthier than most middle-aged and elderly people], modest sleep loss is associated with significant sleepiness, impairment of psychomotor performance, and increased secretion of pro-inflammatory cytokines.(35).

It is generally accepted that 50 to 75 years ago, most Americans slept eight-nine hours nightly. People in "underdeveloped" nations, without widespread access to artificial light, frequently sleep more than that. Recent surveys of Americans' sleep habits show that many Americans now rely on only six or less hours of sleep nightly. These Americans can look forward to a lifetime of gradually increasing inflammatory status. As Vgontzas and coworkers point out, "the idea that sleep or parts of it are optional should be regarded with caution." (35).

Aging and Inflammation

There are various biological changes that occur with aging that unfortunately tend to promote chronic inflammation. With menopause, women typically suffer a drastic decrease in circulating estrogens. During the generally more gradual andropause, men tend to suffer reduced free testosterone. The adrenal steroid DHEA also shows a steep drop with aging, (44) as does the pineal hormone melatonin. (45). Cortisol levels tend to increase with age, as do adrenalin/noradrenalin. (3). Unfortunately, all these changes tend to promote inflammation.

Interleukin-6 is one of the most powerful and significant pro-inflammatory cytokines. (3). It is secreted by a wide range of cells. (3) It promotes the liver's release of acute phase (inflammation) reaction products, including pro-inflammatory C-reactive protein and fibrinogen.(3), (13). (Fibrinogen, formerly considered only a pro-coagulation factor, is now considered an inflammatory factor, as well.(47)

Interleukin-6 promotes a wide range of pathology, including diabetes, (17) cancer, (10) age-related frailty, (4), (5) insulin resistance, (46) heart disease (Fig. 1), (20), (21), (47) osteoporosis, (3) the "euthyroid sick syndrome" (reduced T3 levels),3 rheumatoid arthritis, (3). Alzheimer's disease, (48), and obesity. (26). Interleukin-6 levels tend to increase with age. (3)

Estrogen and testosterone tend to suppress interleukin-6 secretion, but these hormones decrease after menopause and andropause (3). DHEA suppresses interleukin-6 secretion, but DHEA levels drop drastically from age 15 to 75. (44) Adrenalin and noradrenalin promote interleukin-6 secretion, and they tend to increase with age.(3) Thus, it is hardly surprising that interleukin-6 levels tend to increase with age.

Five-lipoxygenase is an enzyme that increases with aging. (45), (49). It converts arachidonic acid into the powerful inflammatory leukotrienes. (45), (49).

Leukotrienes promote cancer, (18) damage the brain, (45) promote asthma, (18) arthritis, (18) psoriasis (18) and ulcerative colitis. (18). They may also promote atherosclerosis.(56) The 5-lipoxygenase enzyme is activated by glucocorticoids (cortisol), (49) and inhibited by melatonin. (45), (49). Unfortunately, aging and interleukin-6 increase cortisol in humans, (3), (50) while melatonin decreases drastically with aging. (51).

Stress and Inflammation

Stress is almost the hallmark of modern life. Overwork, lack of sleep, loud noise, congested traffic, fear of crime, and worry over money are just some of the many routine modern triggers of stress. The stress response involves the release of adrenalin, noradrenalin, and cortisol from the adrenal glands. (50)

While occasional stress in not toxic, and may even have tonic-like effects, excessive, unremitting stress gradually wears out the machinery of life. (50) And as just noted in the preceding section, adrenalin, noradrenalin, and cortisol promote inflammation, through increasing secretion of interleukin-6 and promoting production of super-inflammatory leukotrienes. Chronic cortisol excess also promotes obesity, (42) and as previously noted obesity promotes secretion of several major inflammatory mediators.

According to a 2003 study, "Production of IL-6 and other pro-inflammatory cytokines can be directly stimulated by depression and other negative emotions and stressful experiences.(57)

A recent study found that among elderly persons experiencing severe chronic stress from home-caring for a spouse suffering Alzheimer's disease, the levels of serum interleukin-6 increased over the six-year course of the study at a rate 400 percent higher than among age-matched non-caregiver controls. (57) Thus a life of chronic, unrelieved stress will promote chronic inflammation as well.

Measuring Inflammation

There are many mediators of inflammation that are measured in scientific experiments. These include tumor necrosis factor-alpha, prostaglandins, thromboxanes, leukotrienes, interleukin-1 and -6, and nuclear factor kappa Beta, to name just a few. Yet only two tests are available for routine clinical use: C-reactive protein (52) and interleukin-6. (47)

hese two inflammatory markers have been shown to be strongly associated with many diseases and conditions related to inflammation, so their levels can provide useful information about one's inflammatory status. There is no absolute number for C-reactive protein or interleukin-6 that is ideal, but obviously in general the lower the measured levels are the better.

C-reactive protein can be elevated by acute infections and injuries, as well as chronic inflammation, so a complete medical examination to rule out current infections or other acute increases of C-reactive protein is the best way to get an accurate picture of one's chronic inflammation level through C-reactive protein testing. A level lower than 0.5mg/L is generally a good sign, while a level of 2 to 3 mg/L or more is cause for concern. (47)

Interleukin-6 is necessary for a functioning immune system, so some is necessary. A level below 0.93pg/ml is a generally good sign, while a level of1.50 pg/ml or above may be cause for concern. (47)

Biosyntrx Supports An Anti-Inflammation Lifestyle

Just as the typical American diet and lifestyle promotes chronic inflammation, a more sensible one can reduce inflammation. Getting regular vigorous exercise tends to reduce C-reactive protein. (27) Brisk walking after meals will tend to reduce insulin resistance and high blood sugar spikes, since exercising muscles can remove glucose from blood without insulin. (53) And reducing insulin resistance will reduce C-reactive protein and fibrinogen. (16) While many physicians assume that C-reactive protein is simply a general marker (indicator) of inflammation, there is a growing body of evidence that C-reactive protein can directly promote inflammation. (13), (54)

Getting seven to eight hours of sleep nightly is an important way to reduce interleukin-6 levels, one of the most powerful pro-inflammatory factors.(3),(35). Losing weight, especially of the "beer belly" variety, will reduce secretion of interleukin-6 and tumor necrosis factor-alpha. (25), (26). Substituting olive oil for linoleic acid-rich vegetable oils, while adding freshly-ground flax seeds and fresh cold-water fish to the diet will improve the omega-6-to-omega-3 balance in the anti-inflammatory direction. (39), (40) The same study that found that linoleic acid powerfully turned on inflammatory gene activity, also found that oleic acid, which makes up almost 80 percent of olive oil, tended to reduce inflammatory gene activity. (41)

Avoiding hydrogenated vegetable oils and canola oil, margarines and baked goods will seriously reduce pro-inflammatory fatty acids. Read food labels. Eliminating deep-fried and overcooked foods will reduce dietary "glycotoxins" (AGEs), with consequent reductions in C-reactive protein, tumor necrosis factor-alpha, and other inflammatory mediators. (36), (37)

Seriously reducing the high sugar/ starch junk foods typical of the American diet will reduce C-reactive protein, especially in those overweight. (31) It will also reduce production of inflammation-promoting AGEs in the body caused by frequent blood sugar spikes. (38) Finding ways to reduce stress will tend to lower interleukin-6 and inflammatory leukotrienes.(3), (49)

Proper dental care to reduce gingivitis and periodontal disease will also reduce many inflammatory mediators. (43) Quitting smoking will reduce C-reactive protein and other inflammatory mediators. (13).

Meet your anti-inflammatory micronutrient needs by trying your best to consume the new recommendation of nine to thirteen servings of multi-colored fruits and vegetables a day. A serving is about one half cup.

James South, MA - with permission from VRP

Ellen Troyer, MT MA - Biosyntrx CEO / Chief Research Officer

PEARL

Given that chronic inflammation is now referred to as " The Plague of Our Time" and given the role that inflammation plays in the development of degenerative disease including eye diseases, it is most fitting that we dedicate and attribute this Friday Pearl research to James South, MA., a noted biochemist in the field of nutritional medicine. James was deeply involved with international nutritional medicine research and was considered to be one of the leading nutritional medicine formulators in the world. He was a prolific science writer, and the editor-in-chief of the much respected Optimal Health Review. Unfortunately, he died a quick death from an aggressive brain tumor a few years ago. He is missed by his world-wide colleagues including those at Biosyntrx and VRP.

Crestpoint Management, LTD instrument announcement:
Inamura Talon Prechopper Forceps 2-2-818

References

1. Chellam Jack. The Inflammation Syndrome. John Wiley & Sons, Hoboken, NJ, 2003. Pp 155-218.

2. The Life Extension Foundation. Disease Prevention and Treatment. Life Extension Media, Hollywood, FL, 2003. Pp. 929-30.

3. Papanicolaou DA et al. The pathophysiologic roles of interleukin-6 in human disease. Ann Int Med 1998, 128:127-37.

4. Cohen HJ et al. The association of plasma IL-6 levels with functional disability in community-dwelling elderly. J Gerontol 1997, 52:M201-08.

5. Ershler, WB, Keller ET. Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med 2000, 51:245-70.

6. Ford DE et al. Depression and C-reactive protein in US adults. Arch Intern Med 2004, 164:1010-14.

7. Kop WJ et al. Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol 2002, 89:419-24.

8. Seddon JM et al. Association between C-reactive protein and age-related macular degeneration. JAMA 2004, 291: 704-10.

9. Anderson, Douglas et al. Mosby's Medical Dictionary. Mosby, St. Louis, 2002. Pg 893.

10. Caruso C et al. Aging, longevity, inflammation, and cancer. Ann NY Acad Sci 2004, 1028:1-13.

11. Guyton Arthur, Hall John. Textbook of Medical Physiology. WB Saunders, Philadelphia, 2000. Pp 392-401.

12. Papanicolaou DA, Vgontzas AN. Editorial: Interleukin-6: The endocrine cytokine. J Clin Endocrinol Metab 2000, 85:1331-33.

13. Pepys MB, Hirschfeld GM. C-reactive protein: a critical update. J Clin Invest 2003, 111:1805-12.

14. Visser M et al. Elevated C-reactive protein levels in overweight and obese adults. JAMA 1999, 282:2131-35.

15. Xu H et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003, 112: 1821-30.

16. Festa A et al. Chronic subclinical inflammation as part of the insulin resistance syndrome. Circ 2000, 102:42-47.

17. Pradhan AD et al. C-reactive protein, interleukin-6, and risk of developing type 2 diabetes. JAMA 2001, 286:327-34.

18. Steele VE et al. Lipoxygenase inhibitors as potential cancer chemopreventives. Cancer Epidemiol Biomarkers Prev 1999, 8:467-83.

19. Prescott SM, Fitzpatrick FA. Cyclooxygenase-2 and carcinogenesis. Biochem Biophys Acta 2000, 1470:M69-78.

20. Cesari M et al. Inflammatory markers and onset of cardiovascular events. Circ 2003, 108:2317-22.

21. Ridker PM et al. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently health men. Circ 2000, 101:1767-72.

22. Schmidt R et al. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia Aging Study. Ann Neurol 2002, 52:168-74.

23. McGreer PL, McGreer EG. Inflammation and the degenerative diseases of aging. Ann NY Acad Sci 2004, 1035:104-16.

24. Lee Y-H, Pratley RE. The evolving role of inflammation in obesity and the metabolic syndrome. Curr Diab Rep 2005, 5:70-75.

25. Hotamisligil GS et al. Increased adipose tissue expression of tumor necrosis factor-[alpha] in human obesity and insulin resistance. J Clin Invest 1995, 95: 2409-15.

26. Khaodhiar L, et al. Serum levels of interleukin-6 and C-reactive protein correlate with body mass index across the broad range of obesity. J Parenter Enteral Nutr 2004, 28:410-15.

27. Ford ES. Does exercise reduce inflammation? Physical activity and C-reactive protein among US adults. Epidemiol 2002, 13: 561-68.

28. Baer DJ et al. Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study. Am J Clin Nutr 2004, 79:969-73.

29. Lopez-Garcia E et al. Consumption of trans-fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction. J Nutr 2005, 135:562-66.

30. Mozaffarian D et al. trans Fatty acids and systemic inflammation in heart failure. Am J Clin Nutr 2004, 80:1521-25.

31. Liu S et al. Relation between a diet with a high glycemic load and plasma concentrations of high-sensitivity C-reactive protein in middle-aged women. Am J Clin Nutr 2002, 75:492-98.

32. Subar AF et al. Dietary sources of nutrients among US adults, 1989 to 1991. J Am Diet Assoc 1998, 98:537-47.

33. Vgontzas AN et al. Circadian interleukin-6 secretion and quantity and depth of sleep. J Clin Endocrinol Metab 1999, 84:2603-07.

34. Vgontzas AN, Chrousos GP. Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders. Endocrinol Metab Clin North Am2002, 31:15-36.

35. Vgontzas AN et al. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J Clin Endocrinol Metab 2004, 89:2119-26.

36. Peppa M et al. Glycoxidation and inflammation in renal failure patients. Am J Kidney Dis 2004, 43:690-95.

37. Vlassara H et al. Inflammatory mediators are induced by dietary glycotoxins, a major risk factor for diabetic angioplathy. Proc Natl Acad Sci USA 2002, 99:15596-601.

38. Dean W, South J. Preventing AGEs and cross-linkages: a comprehensive approach. Vit Res News 2004, 18(10):1, 4-7, 13-14.

39. Chellam op cit, pp 28-32.

40. James MJ et al. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am J Clin Nutr 2000, 71 (suppl): 343S-48S.

41. Toborek M et al. Unsaturated fatty acids selectively induce an inflammatory environment in human endothelial cells. Am J Clin Nutr 2002, 75:119-25.

42. Yudkin JS et al. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 2000, 148:209-14.

43. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal disease. J Dent Res 2003, 82:82-90.

44. Straub RH et al. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J Clin Endocrinol Metab 1998, 83:2012-17.

45. Uz T et al. Aging-associated up-regulation of neuronal 5-lipoxygenase expression: putative role in neuronal vulnerability. FASEB J 1998, 12:439-49.

46. Kim H-J et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver action in vivo. Diab 2004, 53:1060-67.

47. Luc G et al. C-reactive protein, interleukin-6, and fibrinogen as predictors of coronary heart disease. The PRIME study. Arterioscler Thromb Vasc Biol 2003, 23:1255-61.

48. Hull M et al. The participation of interleukin-6, a stress-inducible cytokine, in the pathogenesis of Alzheimer's disease. Behav Brain Res 1996, 78: 37-41.

49. Manev H et al. Putative role of neuronal 5-lipoxygenase in an aging brain. FASEB J 2000, 14: 1464-69.

50. Dean W. Adaptive homeostat dysfunction. Vit Res News 2005, 19(2):1-5.

51. Dean W. Neuroendocrine theory of aging: an introduction. Vit Res News 2005, 19(1):1-4.

52. Kluft C, de Maat MP. Editorial: Genetics of C-reactive protein. Arterioscler Thromb Vasc Biol 2003, 23:1956-59.

53. Guyton and Hall op cit, pg 886.

54. Pasceri V et al. Direct pro-inflammatory effect of C-reactive protein on human endothelial cells. Circ 2000, 102:2165-68.

55. BaldwinAS. The transcription factor NF-kB and human disease. J Clin Invest 2001, 107:3-6.

56. Rasmark O. Editorial: 5-lipoxygenase-derived leukotrienes. Mediators also of atherosclerotic inflammation. Arterioscler Thromb Vasc Biol 2003, 23:1140-42.

57. Kiecolt-Glaser JK, et al. Chronic stress and age-related increases in the pro-inflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003, 100:9090-95.

R and N Blog